Now a days, scientists like to find about association of major genes and quantitative traits. In the first step, breeding value of quantitative trait should be predicted and genotype of animals for special major gene locus should be detected. Then, GLM analyses are used to compare all levels of genotypes and study about their association with quantitative traits. The accuracy of prediction of breeding value may influence the result of analyses. Different models with different accuracy of prediction may be utilized to predict breeding value. In this article, different models, with and without using the Genotypic Data of Major Genes Loci were used in order to identify the better model for genetic evaluation in this situation.